Overview
Innovative testing of new raw materials and products can be conducted using the OMICA Oral. This platform is designed to provide the 3D Oral Model. One of the key advantages is its enhanced predictive capability in comparison to conventional in-vitro methods. This is due to the fact that human oral cells are used in a three-dimensional environment, resulting in a more accurate representation of native human oral cavity.
Description
The 3D oral irritation model is an advanced in vitro system developed for the assessment of potential irritancy in the oral cavity. It is constructed using human oral keratinocytes cultured in a three-dimensional environment that closely resembles the native oral tissue structure. The model incorporates a stratified epithelial layer composed of differentiated cells representing the different layers of the oral mucosa, including the epithelium, lamina propria, and submucosa.
The epithelial layer forms the outermost barrier of the model, consisting of basal cells, spinous cells, and a superficial layer of squamous cells, mirroring the natural structure of the oral epithelium. The lamina propria, situated beneath the epithelium, contains fibroblasts, immune cells, blood vessels, and extracellular matrix components, replicating the supportive connective tissue layer in the oral mucosa. The submucosa, located beneath the lamina propria, represents the deeper tissue layer, consisting of adipocytes, salivary glands, and nerves.
Aim
The 3D oral irritation model is a cutting-edge in vitro system that simulates the complex environment of the oral cavity. It is created using cultured human oral cells, such as oral keratinocytes, and is designed to mimic the structure and functionality of native oral tissues. This model provides a valuable tool for evaluating the irritancy potential of various oral care products, including toothpaste, mouthwash, and dental materials. By exposing the model to these substances, researchers can assess their effects on oral tissues, including irritation, inflammation, and damage. The 3D oral irritation model offers a cost-effective and ethical alternative to traditional animal testing methods, while providing valuable insights into the safety and efficacy of oral care formulations.
